TY - JOUR T1 - Virtual screening of inhibitors for the Zika virus proteins JF - bioRxiv DO - 10.1101/060798 SP - 060798 AU - S. Feranchuk AU - U. Potapova AU - S. Belikov Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/27/060798.abstract N2 - The NS3 protease and NS5 polymerase structures of the Zika virus were constructed and processed using a virtual screening pipeline. MM-PBSA calculations show that some of the ligands found by the pipeline demonstrate a good affinity to vulnerable sites in both proteins. The anti-hypertension drug eprosartan is among the selected ligands; and inhibition of the tick-borne encephalitis virus has already been confirmed in vivo by a previous study. In the present study phytochemicals bisabolol and andrographolide are suggested as the candidates for antiviral therapy. ER -