RT Journal Article
SR Electronic
T1 Bottom-up ecology of the human microbiome: from metagenomes to metabolomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 060673
DO 10.1101/060673
A1 Daniel R. Garza
A1 Marcel C. Van Verk
A1 Martijn A. Huynen
A1 Bas E. Dutilh
YR 2016
UL http://biorxiv.org/content/early/2016/06/24/060673.abstract
AB The environmental metabolome is a dominant and essential factor shaping microbial communities. Thus, we hypothesized that metagenomic datasets could reveal the quantitative metabolic status of a given sample. Using a newly developed bottom-up ecology algorithm, we predicted high-resolution metabolomes of hundreds of metagenomic datasets from the human microbiome, revealing body-site specific metabolomes consistent with known metabolomics data, and suggesting that common cosmetics ingredients are some of the major metabolites shaping the human skin microbiome.