PT - JOURNAL ARTICLE AU - Matthew J. Peloquin AU - Dave Bridges TI - Weight Loss in Response to Food Deprivation Predicts the Extent of Diet-Induced Obesity in C57BL/6J Mice AID - 10.1101/004283 DP - 2014 Jan 01 TA - bioRxiv PG - 004283 4099 - http://biorxiv.org/content/early/2014/06/30/004283.short 4100 - http://biorxiv.org/content/early/2014/06/30/004283.full AB - Inbred C57BL/6J mice have been used to study diet-induced obesity and the detrimental physiological effects associated with it. Little is understood about predictive factors that predispose an animal to weight gain. To address this, mice were fed a high fat diet, control diet or normal chow diet. Several measurements including pre-diet serum hormone levels and pre-diet body weight were analyzed, but these had limited predictive value regarding weight gain. However, baseline measurements of weight loss in response to food deprivation showed a strong negative correlation with high fat diet-induced weight gain. These data suggest that fasting-induced weight loss in adolescent mice is a useful predictor of diet-induced weight gain.