RT Journal Article SR Electronic T1 The genetics of an early Neolithic pastoralist from the Zagros, Iran JF bioRxiv FD Cold Spring Harbor Laboratory SP 059568 DO 10.1101/059568 A1 M. Gallego-Llorente A1 S. Connell A1 E. R. Jones A1 D. C. Merrett A1 Y. Jeon A1 A. Eriksson A1 V. Siska A1 C. Gamba A1 C. Meiklejohn A1 R. Beyer A1 S. Jeon A1 Y. S. Cho A1 M. Hofreiter A1 J. Bhak A1 A. Manica A1 R. Pinhasi YR 2016 UL http://biorxiv.org/content/early/2016/06/18/059568.abstract AB The agricultural transition profoundly changed human societies. We sequenced and analysed the first genome (1.39×) of an early Neolithic woman from Ganj Dareh, in the Zagros Mountains of Iran, a site with early evidence for an economy based on goat herding,ca. 10,000 BP. We show that Western Iran was inhabited by a population genetically most similar to hunter-gatherers from the Caucasus, but distinct from the Neolithic Anatolian people who later brought food production into Europe. The inhabitants of Ganj Dareh made little direct genetic contribution to modern European populations, suggesting they were somewhat isolated from other populations in the region. Runs of homozygosity are of a similar length to those from Neolithic Anatolians, and shorter than those of Caucasus and Western Hunter-Gatherers, suggesting that the inhabitants of Ganj Dareh did not undergo the large population bottleneck suffered by their northern neighbours. While some degree of cultural diffusion between Anatolia, Western Iran and other neighbouring regions is possible, the genetic dissimilarity of early Anatolian farmers and the inhabitants of Ganj Dareh supports a model in which Neolithic societies in these areas were distinct.