RT Journal Article
SR Electronic
T1 Genetic variability in both the adaptive and innate immune systems contribute to Alzheimer’s and Parkinson’s disease risk
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 059519
DO 10.1101/059519
A1 Sarah A Gagliano
A1 Jennie G Pouget
A1 John Hardy
A1 Michael R Barnes
A1 Jo Knight
A1 Mina Ryten
A1 Michael E Weale
YR 2016
UL http://biorxiv.org/content/early/2016/06/17/059519.abstract
AB Neurodegenerative disorders are devastating diseases with a worldwide health-care burden. Studies have demonstrated enrichment of disease-associated genetic variants with functional genomic annotations. Determining associated cell-types is important to understand pathogenicity.We obtained GWAS summary statistics from Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and frontotemporal dementia (FTD). We applied stratified LD score regression to determine if functional categories are enriched for heritability.There was little enrichment of brain annotations, but annotations from both the innate and adaptive immune systems were enriched for MS (as expected), AD, and PD, in decreasing order of statistical significance.