RT Journal Article SR Electronic T1 The genetic structure of the world’s first farmers JF bioRxiv FD Cold Spring Harbor Laboratory SP 059311 DO 10.1101/059311 A1 Iosif Lazaridis A1 Dani Nadel A1 Gary Rollefson A1 Deborah C. Merrett A1 Nadin Rohland A1 Swapan Mallick A1 Daniel Fernandes A1 Mario Novak A1 Beatriz Gamarra A1 Kendra Sirak A1 Sarah Connell A1 Kristin Stewardson A1 Eadaoin Harney A1 Qiaomei Fu A1 Gloria Gonzalez-Fortes A1 Songül Alpaslan Roodenberg A1 György Lengyel A1 Fanny Bocquentin A1 Boris Gasparian A1 Janet M. Monge A1 Michael Gregg A1 Vered Eshed A1 Ahuva-Sivan Mizrahi A1 Christopher Meiklejohn A1 Fokke Gerritsen A1 Luminita Bejenaru A1 Matthias Blueher A1 Archie Campbell A1 Gianpero Cavalleri A1 David Comas A1 Philippe Froguel A1 Edmund Gilbert A1 Shona M. Kerr A1 Peter Kovacs A1 Johannes Krause A1 Darren McGettigan A1 Michael Merrigan A1 D. Andrew Merriwether A1 Seamus O’Reilly A1 Martin B. Richards A1 Ornella Semino A1 Michel Shamoon-Pour A1 Gheorghe Stefanescu A1 Michael Stumvoll A1 Anke Tönjes A1 Antonio Torroni A1 James F. Wilson A1 Loic Yengo A1 Nelli A. Hovhannisyan A1 Nick Patterson A1 Ron Pinhasi A1 David Reich YR 2016 UL http://biorxiv.org/content/early/2016/06/16/059311.abstract AB We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000-1,400 BCE, from Natufian hunter-gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a ‘Basal Eurasian’ lineage that had little if any Neanderthal admixture and that separated from other non-African lineages prior to their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local hunter-gatherers. By the time of the Bronze Age, these two populations and Anatolian-related farmers had mixed with each other and with the hunter-gatherers of Europe to drastically reduce genetic differentiation. The impact of the Near Eastern farmers extended beyond the Near East: farmers related to those of Anatolia spread westward into Europe; farmers related to those of the Levant spread southward into East Africa; farmers related to those from Iran spread northward into the Eurasian steppe; and people related to both the early farmers of Iran and to the pastoralists of the Eurasian steppe spread eastward into South Asia.