TY - JOUR T1 - Atypical <em>Salmonella enterica</em> serovars in murine and human infection models: Is it time to reassess our approach to the study of salmonellosis? JF - bioRxiv DO - 10.1101/058610 SP - 058610 AU - Daniel Hurley AU - Maria Hoffmann AU - Tim Muruvanda AU - Marc W. Allard AU - Eric W. Brown AU - Marta Martins AU - Séamus Fanning Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/13/058610.abstract N2 - Nontyphoidal Salmonella species are globally disseminated pathogens and the predominant cause of gastroenteritis. The pathogenesis of salmonellosis has been extensively studied using in vivo murine models and cell lines typically challenged with Salmonella Typhimurium. Although serovars Enteritidis and Typhimurium are responsible for the most of human infections reported to the CDC, several other serovars also contribute to clinical cases of salmonellosis. Despite their epidemiological importance, little is known about their infection phenotypes. Here, we report the virulence characteristics and genomes of 10 atypical S. enterica serovars linked to multistate foodborne outbreaks in the United States. We show that the murine RAW 264.7 macrophage model of infection is unsuitable for inferring human relevant differences in nontyphoidal Salmonella infections whereas differentiated human THP-1 macrophages allowed these isolates to be further characterised in a more relevant, human context. ER -