TY - JOUR T1 - Exposing the Diversity of Multiple Infection Patterns JF - bioRxiv DO - 10.1101/058263 SP - 058263 AU - Mircea T. Sofonea AU - Samuel Alizon AU - Yannis Michalakis Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/10/058263.abstract N2 - Natural populations often have to cope with genetically distinct parasites that can coexist, or not, within the same hosts. Theoretical models addressing the evolution of virulence have considered two within host infection outcomes, namely superinfection and coinfection. The field somehow became limited by this dichotomy that does not correspond to an empirical reality, as other infection patterns, namely sets of within-host infection outcomes, are possible. We indeed formally prove there are 114 different infection patterns for the sole recoverable chronic infections caused by horizontally-transmitted microparasites. We afterwards highlight eight infection patterns using an explicit modelling of within-host dynamics that captures a large range of ecological interactions, five of which have been neglected so far. To clarify the terminology related to multiple infections, we introduce terms describing these new relevant patterns and illustrate them with existing biological systems. This characterisation of infection patterns opens new perspectives for understanding the epidemiology and the evolution of parasites. ER -