TY - JOUR T1 - Differential analysis of RNA-Seq incorporating quantification uncertainty JF - bioRxiv DO - 10.1101/058164 SP - 058164 AU - Harold Pimentel AU - Bray Nicolas L. AU - Suzette Puente AU - Páll Melsted AU - Lior Pachter Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/10/058164.abstract N2 - We describe a novel method for the differential analysis of RNA-Seq data that utilizes bootstrapping in conjunction with response error linear modeling to decouple biological variance from inferential variance. The method is implemented in an interactive shiny app called sleuth that utilizes kallisto quantifications and bootstraps for fast and accurate analysis of RNA-Seq experiments. ER -