RT Journal Article
SR Electronic
T1 DNA sequence properties that predict susceptibility to epiallelic switching
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 057794
DO 10.1101/057794
A1 Marco Catoni
A1 Jayne Griffiths
A1 Claude Becker
A1 Nicolae Radu Zabet
A1 Carlos Bayon
A1 Mélanie Dapp
A1 Michal Lieberman-Lazarovich
A1 Detlef Weigel
A1 Jerzy Paszkowski
YR 2016
UL http://biorxiv.org/content/early/2016/06/08/057794.abstract
AB Transgenerationally heritable epialleles are defined by the stable propagation of alternative transcriptional states through mitotic and meiotic cell cycles. Given that the propagation of DNA methylation at CpG sites, mediated in Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined genome-wide DNA methylation in partial and complete loss-of-function met1 mutants. We interpreted the data in relation to transgenerational epiallelic stability and provide evidence that DNA sequence features such as density of CpGs and genomic repetitiveness can be used to predict susceptibility to epiallelic switching. The importance of these rules was confirmed by analyses of common epialleles in natural Arabidopsis accessions and verified in rice.