RT Journal Article
SR Electronic
T1 Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 057885
DO 10.1101/057885
A1 Bin Wang
A1 Ni Ye
A1 San-jie Cao
A1 Xin-tian Wen
A1 Yongxs Huang
A1 Qi-gui Yan
YR 2016
UL http://biorxiv.org/content/early/2016/06/08/057885.abstract
AB Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive,contact transmitted disease. This study aimed to identify novel and differentially expressed miRNAs in the tumor and para-carcinoma nasal tissuesofNanjiang yellow goats with ENA. Small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library.406 known miRNAs and 29 novel miRNAs were identified. A total of 116 miRNAs were significantly differentially expressed in para-carcinoma nasal tissues and ENA; Target gene prediction and functional analysis revealed that 6176 non-redundancy target genes, 1792 significant GO and 97 significant KEGG pathway for 121 miRNAs were predicted.