PT - JOURNAL ARTICLE AU - Bin Wang AU - Ni Ye AU - San-jie Cao AU - Xin-tian Wen AU - Yongxs Huang AU - Qi-gui Yan TI - Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma AID - 10.1101/057885 DP - 2016 Jan 01 TA - bioRxiv PG - 057885 4099 - http://biorxiv.org/content/early/2016/06/08/057885.short 4100 - http://biorxiv.org/content/early/2016/06/08/057885.full AB - Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive,contact transmitted disease. This study aimed to identify novel and differentially expressed miRNAs in the tumor and para-carcinoma nasal tissuesofNanjiang yellow goats with ENA. Small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library.406 known miRNAs and 29 novel miRNAs were identified. A total of 116 miRNAs were significantly differentially expressed in para-carcinoma nasal tissues and ENA; Target gene prediction and functional analysis revealed that 6176 non-redundancy target genes, 1792 significant GO and 97 significant KEGG pathway for 121 miRNAs were predicted.