RT Journal Article SR Electronic T1 Transcriptional activity of TRF2 is telomere length dependent JF bioRxiv FD Cold Spring Harbor Laboratory SP 056481 DO 10.1101/056481 A1 Ananda Kishore Mukherjee A1 Shalu Sharma A1 Parashar Dhapola A1 Dhurjhoti Saha A1 Tabish Hussain A1 Sumitabho Deb Roy A1 Gunjan Purohit A1 Anirban Kar A1 Ankita Singh A1 Suman Sengupta A1 Vivek Srivastava A1 Manish Kumar A1 Sagar Sengupta A1 Shantanu Chowdhury YR 2016 UL http://biorxiv.org/content/early/2016/06/03/056481.abstract AB TRF2 is a telomere repeat binding factor crucial for telomere maintenance and genome stability. An emerging non-conventional role of TRF2 is as a transcriptional regulator through extra-telomeric bindings. Herein we report that increase in telomere length leads to sequestration of TRF2 at the telomeres leading to reduced extra-telomeric TRF2 occupancy genome wide. Decrease in TRF2 occupancy was found on multiple gene promoters in cells with elongated telomeres, including the cell cycle regulator kinase-p21. We found that TRF2 is a transcriptional repressor of p21, and, interestingly, TRF2-mediated regulatory control of p21 is telomere length dependent.