PT - JOURNAL ARTICLE AU - Ananda Kishore Mukherjee AU - Shalu Sharma AU - Parashar Dhapola AU - Dhurjhoti Saha AU - Tabish Hussain AU - Sumitabho Deb Roy AU - Gunjan Purohit AU - Anirban Kar AU - Ankita Singh AU - Suman Sengupta AU - Vivek Srivastava AU - Manish Kumar AU - Sagar Sengupta AU - Shantanu Chowdhury TI - Transcriptional activity of TRF2 is telomere length dependent AID - 10.1101/056481 DP - 2016 Jan 01 TA - bioRxiv PG - 056481 4099 - http://biorxiv.org/content/early/2016/06/03/056481.short 4100 - http://biorxiv.org/content/early/2016/06/03/056481.full AB - TRF2 is a telomere repeat binding factor crucial for telomere maintenance and genome stability. An emerging non-conventional role of TRF2 is as a transcriptional regulator through extra-telomeric bindings. Herein we report that increase in telomere length leads to sequestration of TRF2 at the telomeres leading to reduced extra-telomeric TRF2 occupancy genome wide. Decrease in TRF2 occupancy was found on multiple gene promoters in cells with elongated telomeres, including the cell cycle regulator kinase-p21. We found that TRF2 is a transcriptional repressor of p21, and, interestingly, TRF2-mediated regulatory control of p21 is telomere length dependent.