RT Journal Article SR Electronic T1 Fast and Robust Segmentation of Copy Number Profiles Using Multi-Scale Edge Detection JF bioRxiv FD Cold Spring Harbor Laboratory SP 056705 DO 10.1101/056705 A1 Ivo W Kwee A1 Andrea Rinaldi A1 Cassio Polpo de Campos A1 Francesco Bertoni YR 2016 UL http://biorxiv.org/content/early/2016/06/02/056705.abstract AB Raw copy number data is highly dimensional, noisy and can suffer from so-called genomic wave artifacts. We introduce a novel method based on multi-scale edge detection in derivative space. By using derivatives, the algorithm was very fast and robust against genomic waves. Our method compared very well to existing state-of-the-art segmentation methods and importantly outperformed these if noise and wave artifacts were well present.