TY - JOUR T1 - Fast and Robust Segmentation of Copy Number Profiles Using Multi-Scale Edge Detection JF - bioRxiv DO - 10.1101/056705 SP - 056705 AU - Ivo W Kwee AU - Andrea Rinaldi AU - Cassio Polpo de Campos AU - Francesco Bertoni Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/06/02/056705.abstract N2 - Raw copy number data is highly dimensional, noisy and can suffer from so-called genomic wave artifacts. We introduce a novel method based on multi-scale edge detection in derivative space. By using derivatives, the algorithm was very fast and robust against genomic waves. Our method compared very well to existing state-of-the-art segmentation methods and importantly outperformed these if noise and wave artifacts were well present. ER -