TY - JOUR T1 - Enhancing synergy of CAR T cell therapy and oncolytic virus therapy for pancreatic cancer JF - bioRxiv DO - 10.1101/055988 SP - 055988 AU - Rachel Walker AU - Pedro E. Navas AU - Samuel H. Friedman AU - Simona Galliani AU - Aleksandra Karolak AU - Fiona Macfarlane AU - Robert Noble AU - Jan Poleszczuk AU - Shonagh Russell AU - Katarzyna A. Rejniak AU - Amir Shahmoradi AU - Frederik Ziebell AU - Jason Brayer AU - Daniel Abate-Daga AU - Heiko Enderling Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/05/30/055988.abstract N2 - The poor immunogenicity of pancreatic tumors makes them particularly difficult to treat. Standard chemotherapies and single agent immunotherapies have had notoriously little success in this arena. Oncolytic virus therapy has the potential to enhance the penetration of immunotherapeutically-delivered CAR T cells into the tumor and improve treatment outcomes. We evaluate this potential by combining two different mathematical approaches: an ordinary differential equation model to simulate population level tumor response to cytotoxic activity of T cells, coupled with an agent-based model to simulate the enhancement of CAR T cell penetration by oncolytic virus therapy. ER -