PT  - JOURNAL ARTICLE
AU  - Rachel Walker
AU  - Pedro E. Navas
AU  - Samuel H. Friedman
AU  - Simona Galliani
AU  - Aleksandra Karolak
AU  - Fiona Macfarlane
AU  - Robert Noble
AU  - Jan Poleszczuk
AU  - Shonagh Russell
AU  - Katarzyna A. Rejniak
AU  - Amir Shahmoradi
AU  - Frederik Ziebell
AU  - Jason Brayer
AU  - Daniel Abate-Daga
AU  - Heiko Enderling
TI  - Enhancing synergy of CAR T cell therapy and oncolytic virus therapy for pancreatic cancer
AID  - 10.1101/055988
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 055988
4099  - http://biorxiv.org/content/early/2016/05/30/055988.short
4100  - http://biorxiv.org/content/early/2016/05/30/055988.full
AB  - The poor immunogenicity of pancreatic tumors makes them particularly difficult to treat. Standard chemotherapies and single agent immunotherapies have had notoriously little success in this arena. Oncolytic virus therapy has the potential to enhance the penetration of immunotherapeutically-delivered CAR T cells into the tumor and improve treatment outcomes. We evaluate this potential by combining two different mathematical approaches: an ordinary differential equation model to simulate population level tumor response to cytotoxic activity of T cells, coupled with an agent-based model to simulate the enhancement of CAR T cell penetration by oncolytic virus therapy.