@article {Niederhuth045880, author = {Chad E. Niederhuth and Adam J. Bewick and Lexiang Ji and Magdy S. Alabady and Kyung Do Kim and Qing Li and Nicholas A. Rohr and Aditi Rambani and John M. Burke and Josh A. Udall and Chiedozie Egesi and Jeremy Schmutz and Jane Grimwood and Scott A. Jackson and Nathan M. Springer and Robert J. Schmitz}, title = {Widespread natural variation of DNA methylation within angiosperms}, elocation-id = {045880}, year = {2016}, doi = {10.1101/045880}, publisher = {Cold Spring Harbor Laboratory}, abstract = {To understand the variation in genomic patterning of DNA methylation we compared methylomes of 34 diverse angiosperm species. By analyzing whole-genome bisulfite sequencing data in a phylogenetic context it becomes clear that there is extensive variation throughout angiosperms in gene body DNA methylation, euchromatic silencing of transposons and repeats, as well as silencing of heterochromatic transposons. The Brassicaceae have reduced CHG methylation levels and also reduced or loss of CG gene body methylation. The Poaceae are characterized by a lack or reduction of heterochromatic CHH methylation and enrichment of CHH methylation in genic regions. Reduced CHH methylation levels are found in clonally propagated species, suggesting that these methods of propagation may alter the epigenomic landscape over time. These results show that DNA methylation patterns are broadly a reflection of the evolutionary and life histories of plant species.}, URL = {https://www.biorxiv.org/content/early/2016/05/28/045880}, eprint = {https://www.biorxiv.org/content/early/2016/05/28/045880.full.pdf}, journal = {bioRxiv} }