TY - JOUR T1 - Disruption of Human <em>astn2</em> Function by ZIKV <em>ns4b</em> Gene as a Molecular Basis for Zika Viral Microcephaly JF - bioRxiv DO - 10.1101/054486 SP - 054486 AU - Bhaskar Ganguly AU - Enakshi Ganguly Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/05/20/054486.abstract N2 - The present Zika virus (ZIKV) pandemic is being associated with increased incidence of microcephaly in newborns. However, a molecular basis for such pathogenesis is distinctly lacking. Comparative nucleic acid sequence analysis showed similarity between regions of non-structural protein 4B (ns4b) gene of ZIKV and human astrotactin2 (astn2) gene. Based on these findings, a molecular target of Zika viral microcephaly is being proposed. ER -