RT Journal Article
SR Electronic
T1 Disruption of Human <em>astn2</em> Function by ZIKV <em>ns4b</em> Gene as a Molecular Basis for Zika Viral Microcephaly
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 054486
DO 10.1101/054486
A1 Bhaskar Ganguly
A1 Enakshi Ganguly
YR 2016
UL http://biorxiv.org/content/early/2016/05/20/054486.abstract
AB The present Zika virus (ZIKV) pandemic is being associated with increased incidence of microcephaly in newborns. However, a molecular basis for such pathogenesis is distinctly lacking. Comparative nucleic acid sequence analysis showed similarity between regions of non-structural protein 4B (ns4b) gene of ZIKV and human astrotactin2 (astn2) gene. Based on these findings, a molecular target of Zika viral microcephaly is being proposed.