RT Journal Article
SR Electronic
T1 The wiring diagram of a glomerular olfactory system
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 037721
DO 10.1101/037721
A1 Matthew E. Berck
A1 Avinash Khandelwal
A1 Lindsey Claus
A1 Luis Hernandez-Nunez
A1 Guangwei Si
A1 Christopher J. Tabone
A1 Feng Li
A1 James W. Truman
A1 Richard D. Fetter
A1 Matthieu Louis
A1 Aravinthan D.T. Samuel
A1 Albert Cardona
YR 2016
UL http://biorxiv.org/content/early/2016/05/12/037721.abstract
AB The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior.