RT Journal Article
SR Electronic
T1 Cancer-associated recurrent mutations in RNase III domains of DICER1
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 005686
DO 10.1101/005686
A1 Bülent Arman Aksoy
A1 Anders Jacobsen
A1 Robert J. Fieldhouse
A1 William Lee
A1 Emek Demir
A1 Giovanni Ciriello
A1 Nikolaus Schultz
A1 Debora S. Marks
A1 Chris Sander
YR 2014
UL http://biorxiv.org/content/early/2014/05/29/005686.abstract
AB Biallelic somatic mutations in the RNase IIIb domain of DICER1 are recurrent in different cancer types, disrupting the processing of the 5p, but not 3p, strand of the pre-miRNAs. Using data from the Cancer Genome Atlas project, we showed these mutations cause 5p-strand miRNA depletion, which in turn causes up-regulation of targets of particular miRNA families in human tumors. Furthermore, we identified a previously unknown re-current mutation in the RNase IIIa domain that also disrupts 5p-strand processing.