TY - JOUR T1 - Mega-analysis of 31,396 individuals from 6 countries uncovers strong gene-environment interaction for human fertility JF - bioRxiv DO - 10.1101/049163 SP - 049163 AU - Felix C. Tropf AU - Renske M. Verweij AU - Peter J. van der Most AU - Gert Stulp AU - Andrew Bakshi AU - Daniel A. Briley AU - Matthew Robinson AU - Anastasia Numan AU - Tõnu Esko AU - Andres Metspalu AU - Sarah E. Medland AU - Nicholas G. Martin AU - Harold Snieder AU - S. Hong Lee AU - Melinda C. Mills Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/05/02/049163.abstract N2 - Family and twin studies suggest that up to 50% of individual differences in human fertility within a population might be heritable. However, it remains unclear whether the genes associated with fertility outcomes such as number of children ever born (NEB) or age at first birth (AFB) are the same across geographical and historical environments. By not taking this into account, previous genetic studies implicitly assumed that the genetic effects are constant across time and space. We conduct a mega-analysis applying whole genome methods on 31,396 unrelated men and women from six Western countries. Across all individuals and environments, common single-nucleotide polymorphisms (SNPs) explained only ~4% of the variance in NEB and AFB. We then extend these models to test whether genetic effects are shared across different environments or unique to them. For individuals belonging to the same population and demographic cohort (born before or after the 20th century fertility decline), SNP-based heritability was almost five times higher at 22% for NEB and 19% for AFB. We also found no evidence suggesting that genetic effects on fertility are shared across time and space. Our findings imply that the environment strongly modifies genetic effects on the tempo and quantum of fertility, that currently ongoing natural selection is heterogeneous across environments, and that gene-environment interactions may partly account for missing heritability in fertility. Future research needs to combine efforts from genetic research and from the social sciences to better understand human fertility.Authors Summary Fertility behavior – such as age at first birth and number of children – varies strongly across historical time and geographical space. Yet, family and twin studies, which suggest that up to 50% of individual differences in fertility are heritable, implicitly assume that the genes important for fertility are the same across both time and space. Using molecular genetic data (SNPs) from over 30,000 unrelated individuals from six different countries, we show that different genes influence fertility in different time periods and different countries, and that the genetic effects consistently related to fertility are presumably small. The fact that genetic effects on fertility appear not to be universal could have tremendous implications for research in the area of reproductive medicine, social science and evolutionary biology alike. ER -