TY - JOUR T1 - Ex-STORM: Expansion Single Molecule Super-resolution Microscopy JF - bioRxiv DO - 10.1101/049403 SP - 049403 AU - Zhisong Tong AU - Paolo Beuzer AU - Qing Ye AU - Josh Axelrod AU - Zhenmin Hong AU - Hu Cang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/04/25/049403.abstract N2 - We present critical improvements to recently invented Expansion Microscopy (ExM), which resolve the incompatibility between ExM and single molecule super-resolution microscopy STORM. Specifically, the improved ExM circumvents the massive, 50-100%, bleaching of fluorophores during sample preparations, and preserve the efficiency of enzymatic oxygen scavenging systems in expanded samples. These improvements open up new avenues for Ex-STORM - expanding a sample mechanically, and then visualizing the sample with STORM. ER -