PT  - JOURNAL ARTICLE
AU  - Kathleen P. Wilkie
AU  - Philip Hahnfeldt
AU  - Lynn Hlatky
TI  - Using Ordinary Differential Equations to Explore Cancer-Immune Dynamics and Tumor Dormancy
AID  - 10.1101/049874
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 049874
4099  - http://biorxiv.org/content/early/2016/04/22/049874.short
4100  - http://biorxiv.org/content/early/2016/04/22/049874.full
AB  - Cancer is not solely a disease of the genome, but is a systemic disease that affects the host on many functional levels, including, and perhaps most notably, the function of the immune response, resulting in both tumor-promoting inflammation and tumor-inhibiting cytotoxic action. The dichotomous actions of the immune response induce significant variations in tumor growth dynamics that mathematical modeling can help to understand. Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.