TY - JOUR T1 - Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients JF - bioRxiv DO - 10.1101/049791 SP - 049791 AU - Philipp A. Jaeger AU - Trisha M. Stan AU - Eva Czirr AU - Markus Britschgi AU - Daniela Berdnik AU - Ruo-Pan Huang AU - Bradley F. Boeve AU - Adam L. Boxer AU - NiCole Finch AU - Gabriela K. Fragiadakis AU - Neill R. Graff-Radford AU - Ruochun Huang AU - Hudson Johns AU - Anna Karydas AU - David S. Knopman AU - Michael Leipold AU - Holden Maecker AU - Zachary Miller AU - Ronald C. Petersen AU - Rosa Rademakers AU - Chung-Huan Sun AU - Steve Younkin AU - Bruce L. Miller AU - Tony Wyss-Coray Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/04/22/049791.abstract N2 - The growing link between systemic environment and brain function opens the possibility that cellular communication and composition in blood are correlated with brain health. We tested this concept in frontotemporal dementia with novel, unbiased tools that measure hundreds of soluble signaling proteins or characterize the vast immune cell repertoire in blood. With these tools we discovered complementary abnormalities indicative of abnormal T cell populations and autoimmunity in frontotemporal dementia. ER -