TY - JOUR T1 - Impact of knowledge accumulation on pathway enrichment analysis JF - bioRxiv DO - 10.1101/049288 SP - 049288 AU - Lina Wadi AU - Mona Meyer AU - Joel Weiser AU - Lincoln D. Stein AU - Jüri Reimand Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/04/19/049288.abstract N2 - Pathway-based interpretation of gene lists is a staple of genome analysis. It depends on frequently updated gene annotation databases. We analyzed the evolution of gene annotations over the past seven years and found that the vocabulary of pathways and processes has doubled. This strongly impacts practical analysis of genes: 80% of publications we surveyed in 2015 used outdated software that only captured 20% of pathway enrichments apparent in current annotations. ER -