RT Journal Article SR Electronic T1 Analysis of shared heritability in common disorders of the brain JF bioRxiv FD Cold Spring Harbor Laboratory SP 048991 DO 10.1101/048991 A1 V Anttila A1 B Bulik-Sullivan A1 H Finucane A1 J Bras A1 L Duncan A1 V Escott-Price A1 G Falcone A1 P Gormley A1 R Malik A1 N Patsopoulos A1 S Ripke A1 R Walters A1 Z Wei A1 D Yu A1 PH Lee A1 IGAP consortium A1 IHGC consortium A1 ILAE Consortium on Complex Epilepsies A1 IMSGC consortium A1 IPDGC consortium A1 METASTROKE and ICH Studies of the ISGC A1 ADHD Working Group of the PGC A1 Anorexia Nervosa Working Group of the PGC A1 ASD Working Group of the PGC A1 Bipolar Disorders Working Group of the PGC A1 Major Depressive Disorder Working Group of the PGC A1 OCD and TS Working Group of the PGC A1 Schizophrenia Working Group of the PGC A1 G Breen A1 C Bulik A1 M Daly A1 M Dichgans A1 S Faraone A1 R Guerreiro A1 P Holmans A1 K Kendler A1 B Koeleman A1 CA Mathews A1 JM Scharf A1 P Sklar A1 J Williams A1 N Wood A1 C Cotsapas A1 A Palotie A1 JW Smoller A1 P Sullivan A1 J Rosand A1 A Corvin A1 BM Neale A1 on behalf of the Brainstorm consortium YR 2016 UL http://biorxiv.org/content/early/2016/04/16/048991.abstract AB Disorders of the brain exhibit considerable epidemiological comorbidity and frequently share symptoms, provoking debate about the extent of their etiologic overlap. Here we apply linkage disequilibrium score regression (LDSC) to quantify the extent of shared genetic contributions across 23 brain disorders (n=842,820), 11 quantitative and four dichotomous traits of interest (n=722,125)based on genome-wide association meta-analyses. Psychiatric disorders show substantial sharing of common variant risk, while many neurological disorders appear more distinct from one another, suggesting substantive differences in the specificity of the genetic etiology of these disorders. Further, we observe little evidence of widespread sharing of the common genetic risk between neurological and psychiatric disorders studied. In addition, we identify significant sharing of genetic influences between the certain quantitative measures and brain disorders, including major depressive disorder and neuroticism personality score. These results highlight the importance of common genetic variation as a source of risk for brain disorders and the potential of using heritability methods to obtain a more comprehensive view of the genetic architecture of brain phenotypes.One Sentence Summary: Comprehensive heritability analysis of brain phenotypes demonstrates a clear role for common genetic variation across neurological and psychiatric disorders, with substantial overlap within the latter.