TY - JOUR T1 - Analysis of shared heritability in common disorders of the brain JF - bioRxiv DO - 10.1101/048991 SP - 048991 AU - V Anttila AU - B Bulik-Sullivan AU - H Finucane AU - J Bras AU - L Duncan AU - V Escott-Price AU - G Falcone AU - P Gormley AU - R Malik AU - N Patsopoulos AU - S Ripke AU - R Walters AU - Z Wei AU - D Yu AU - PH Lee AU - IGAP consortium AU - IHGC consortium AU - ILAE Consortium on Complex Epilepsies AU - IMSGC consortium AU - IPDGC consortium AU - METASTROKE and ICH Studies of the ISGC AU - ADHD Working Group of the PGC AU - Anorexia Nervosa Working Group of the PGC AU - ASD Working Group of the PGC AU - Bipolar Disorders Working Group of the PGC AU - Major Depressive Disorder Working Group of the PGC AU - OCD and TS Working Group of the PGC AU - Schizophrenia Working Group of the PGC AU - G Breen AU - C Bulik AU - M Daly AU - M Dichgans AU - S Faraone AU - R Guerreiro AU - P Holmans AU - K Kendler AU - B Koeleman AU - CA Mathews AU - JM Scharf AU - P Sklar AU - J Williams AU - N Wood AU - C Cotsapas AU - A Palotie AU - JW Smoller AU - P Sullivan AU - J Rosand AU - A Corvin AU - BM Neale AU - on behalf of the Brainstorm consortium Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/04/16/048991.abstract N2 - Disorders of the brain exhibit considerable epidemiological comorbidity and frequently share symptoms, provoking debate about the extent of their etiologic overlap. Here we apply linkage disequilibrium score regression (LDSC) to quantify the extent of shared genetic contributions across 23 brain disorders (n=842,820), 11 quantitative and four dichotomous traits of interest (n=722,125)based on genome-wide association meta-analyses. Psychiatric disorders show substantial sharing of common variant risk, while many neurological disorders appear more distinct from one another, suggesting substantive differences in the specificity of the genetic etiology of these disorders. Further, we observe little evidence of widespread sharing of the common genetic risk between neurological and psychiatric disorders studied. In addition, we identify significant sharing of genetic influences between the certain quantitative measures and brain disorders, including major depressive disorder and neuroticism personality score. These results highlight the importance of common genetic variation as a source of risk for brain disorders and the potential of using heritability methods to obtain a more comprehensive view of the genetic architecture of brain phenotypes.One Sentence Summary: Comprehensive heritability analysis of brain phenotypes demonstrates a clear role for common genetic variation across neurological and psychiatric disorders, with substantial overlap within the latter. ER -