TY - JOUR T1 - Third-generation sequencing and the future of genomics JF - bioRxiv DO - 10.1101/048603 SP - 048603 AU - Hayan Lee AU - James Gurtowski AU - Shinjae Yoo AU - Maria Nattestad AU - Shoshana Marcus AU - Sara Goodwin AU - W. Richard McCombie AU - Michael C. Schatz Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/04/13/048603.abstract N2 - Third-generation long-range DNA sequencing and mapping technologies are creating a renaissance in high-quality genome sequencing. Unlike second-generation sequencing, which produces short reads a few hundred base-pairs long, third-generation single-molecule technologies generate over 10,000 bp reads or map over 100,000 bp molecules. We analyze how increased read lengths can be used to address longstanding problems in de novo genome assembly, structural variation analysis and haplotype phasing. ER -