%0 Journal Article %A Anthony Westbrook %A Jordan Ramsdell %A Taruna Aggarwal %A Louisa Normington %A R. Daniel Bergeron %A W. Kelley Thomas %A Matthew MacManes %T PALADIN:Protein Alignment for Functional Profiling Whole Metagenome Shotgun Data %D 2016 %R 10.1101/047712 %J bioRxiv %P 047712 %X Whole metagenome shotgun sequencing is a powerful approach for assaying the functional potential of microbial communities. Presently, we lack tools that efficiently and accurately align DNA reads against protein references, the technique necessary for constructing a functional profile. Here, we present PALADIN—a novel modification of Burrows-Wheeler Aligner that provides more accurate alignment and orders-of-magnitude improved efficiency by directly mapping in protein space. %U https://www.biorxiv.org/content/biorxiv/early/2016/04/07/047712.full.pdf