%0 Journal Article %A Ma Salud Jiménez-Romero %A Montserrat Barcos-Martínez %A Isabel Espejo-Portero %A Antonio Benítez-Burraco %T Language impairment resulting from a de novo deletion of 7q32.1-q33: a case report %D 2016 %R 10.1101/047241 %J bioRxiv %P 047241 %X Chromosome 7 is a hot spot for cognitive disorders involving language deficits. We report on a girl who presents with a cognitive and speech delay, motor problems, hearing loss, and behavioral disturbances, and a de novo deletion within 7q32.1-q33 (chromosome position: chr7:127109685-132492196, hg 18). Several genes involved in brain development and function are located within the deleted region. Many of them are related to developmental disorders encompassing language deficits (dyslexia, speech-sound disorder, and autism). The proband’s phenotype may result from a change in the expression level of some of these genes. %U https://www.biorxiv.org/content/biorxiv/early/2016/04/06/047241.full.pdf