RT Journal Article
SR Electronic
T1 Genetic contributions to self-reported tiredness
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 047290
DO 10.1101/047290
A1 Vincent Deary
A1 Saskia P Hagenaars
A1 Sarah E Harris
A1 W David Hill
A1 Gail Davies
A1 David CM Liewald
A1 International Consortium for Blood Pressure GWAS
A1 CHARGE consortium Aging and Longevity Group
A1 Andrew M McIntosh
A1 Catharine R Gale
A1 Ian J Deary
YR 2016
UL http://biorxiv.org/content/early/2016/04/05/047290.abstract
AB Self-reported tiredness and low energy, often called fatigue, is associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6% and 50%. In the UK Biobank sample (N = 108 976) we carried out a genome-wide association study of responses to the question, “Over the last two weeks, how often have you felt tired or had little energy?” Univariate GCTA-GREML found that the proportion of variance explained by all common SNPs for this tiredness question was 8.4% (SE = 0.6%). GWAS identified one genome-wide significant hit (Affymetrix id 1:64178756_C_T; p = 1.36 x 10-11). LD score regression and polygenic profile analysis were used to test for pleiotropy between tiredness and up to 28 physical and mental health traits from GWAS consortia. Significant genetic correlations were identified between tiredness and BMI, HDL cholesterol, forced expiratory volume, grip strength, HbA1c, longevity, obesity, self-rated health, smoking status, triglycerides, type 2 diabetes, waist-hip ratio, ADHD, bipolar disorder, major depressive disorder, neuroticism, schizophrenia, and verbal-numerical reasoning (absolute rg effect sizes between 0.11 and 0.78). Significant associations were identified between tiredness phenotypic scores and polygenic profile scores for BMI, HDL cholesterol, LDL cholesterol, coronary artery disease, HbA1c, height, obesity, smoking status, triglycerides, type 2 diabetes, and waist-hip ratio, childhood cognitive ability, neuroticism, bipolar disorder, major depressive disorder, and schizophrenia (standardised β’s between −0.016 and 0.03). These results suggest that tiredness is a partly-heritable, heterogeneous and complex phenomenon that is phenotypically and genetically associated with affective, cognitive, personality, and physiological processes.“Hech, sirs! But I’m wabbit, I’m back frae the toon;I ha’ena dune pechin’—jist let me sit doon.From Glesca’By William Dixon Cocker (1882-1970)