RT Journal Article SR Electronic T1 Nucleosome dynamics and maintenance of epigenetic states of CpG islands JF bioRxiv FD Cold Spring Harbor Laboratory SP 047332 DO 10.1101/047332 A1 Ian B. Dodd A1 Kim Sneppen YR 2016 UL http://biorxiv.org/content/early/2016/04/05/047332.abstract AB Methylation in mammalian DNA occurs primarily at CpG sequences. The CpG sites are distributed in high density clusters (or islands) separated by extended regions of low density. Cluster methylation tends to be bimodal, being dominantly unmethylated or mostly methylated. For CpG clusters near promoters, low methylation is associated with transcriptional activity, while high methylation is associated with gene silencing. Alternative CpG methylation states are thought to be stable and heritable, conferring localized epigenetic memory that allows transient signals to create long-lived gene expression states. Positive feedback where methylated CpG sites recruit enzymes that methylate nearby CpGs, does not easily explain that as clusters increase in size or density they change from being primarily methylated to primarily unmethylated. Here, we show that an interaction between the methylation state of a cluster and its occupancy by nucleosomes provides a mechanism to reproduce epigenetic potential and the genome wide systematics of CpG islands.