RT Journal Article
SR Electronic
T1 FOCUS2: agile and sensitive classification of metagenomics data using a reduced database
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 046425
DO 10.1101/046425
A1 Genivaldo Gueiros Z. Silva
A1 Bas E. Dutilh
A1 Robert A. Edwards
YR 2016
UL http://biorxiv.org/content/early/2016/03/31/046425.abstract
AB Summary Metagenomics approaches rely on identifying the presence of organisms in the microbial community from a set of unknown DNA sequences. Sequence classification has valuable applications in multiple important areas of medical and environmental research. Here we introduce FOCUS2, an update of the previously published computational method FOCUS. FOCUS2 was tested with 10 simulated and 543 real metagenomes demonstrating that the program is more sensitive, faster, and more computationally efficient than existing methods.Availability The Python implementation is freely available at https://edwards.sdsu.edu/FOCUS2.Supplementary information available at Bioinformatics online.