RT Journal Article SR Electronic T1 Divergence Model of Protein Evolution JF bioRxiv FD Cold Spring Harbor Laboratory SP 045930 DO 10.1101/045930 A1 Darrell O. Ricke YR 2016 UL http://biorxiv.org/content/early/2016/03/28/045930.abstract AB Analysis of the evolutionary conservation of amino acids is useful for the analysis of sequence variants detected in individuals with regard to possible impact on protein function. Rapid advances in DNA sequencing technologies are enabling affordable access to SNPs, exome sequencing, and whole genome shotgun sequencing. An understanding of the biological processes that have shaped diverging protein sequences aids the interpretation of sequence variants. The divergence model of protein evolution is presented as a general framework for interpreting information available from comparative analysis of protein sequences.