RT Journal Article
SR Electronic
T1 Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 044412
DO 10.1101/044412
A1 Liping Hou
A1 Sarah E. Bergen
A1 Nirmala Akula
A1 Jie Song
A1 Christina M. Hultman
A1 Mikael Landén
A1 Mazda Adli
A1 Martin Alda
A1 Raffaella Ardau
A1 Bárbara Arias
A1 Jean-Michel Aubry
A1 Lena Backlund
A1 Judith A. Badner
A1 Thomas B. Barrett
A1 Michael Bauer
A1 Bernhard T. Baune
A1 Frank Bellivier
A1 Antonio Benabarre
A1 Susanne Bengesser
A1 Wade H. Berrettini
A1 Abesh Kumar Bhattacharjee
A1 Joanna M. Biernacka
A1 Armin Birner
A1 Cinnamon S. Bloss
A1 Clara Brichant-Petitjean
A1 Elise T. Bui
A1 William Byerley
A1 Pablo Cervantes
A1 Caterina Chillotti
A1 Sven Cichon
A1 Francesc Colom
A1 William Coryell
A1 David W. Craig
A1 Cristiana Cruceanu
A1 Piotr M. Czerski
A1 Tony Davis
A1 Alexandre Dayer
A1 Franziska Degenhardt
A1 Maria Del Zompo
A1 J. Raymond DePaulo
A1 Howard J. Edenberg
A1 Bruno étain
A1 Peter Falkai
A1 Tatiana Foroud
A1 Andreas J. Forstner
A1 Louise Frisén
A1 Mark A. Frye
A1 Janice M. Fullerton
A1 Sébastien Gard
A1 Julie S. Garnham
A1 Elliot S. Gershon
A1 Fernando S. Goes
A1 Tiffany A. Greenwood
A1 Maria Grigoroiu-Serbanescu
A1 Joanna Hauser
A1 Urs Heilbronner
A1 Stefanie Heilmann-Heimbach
A1 Stefan Herms
A1 Maria Hipolito
A1 Shashi Hitturlingappa
A1 Per Hoffmann
A1 Andrea Hofmann
A1 Stephane Jamain
A1 Esther Jiménez
A1 Jean-Pierre Kahn
A1 Layla Kassem
A1 John R. Kelsoe
A1 Sarah Kittel-Schneider
A1 Sebastian Kliwicki
A1 Daniel L. Koller
A1 Barbara König
A1 Nina Lackner
A1 Gonzalo Laje
A1 Maren Lang
A1 Catharina Lavebratt
A1 William B. Lawson
A1 Marion Leboyer
A1 Susan G. Leckband
A1 Chunyu Liu
A1 Anna Maaser
A1 Pamela B. Mahon
A1 Wolfgang Maier
A1 Mario Maj
A1 Mirko Manchia
A1 Lina Martinsson
A1 Michael J. McCarthy
A1 Susan L. McElroy
A1 Melvin G. McInnis
A1 Rebecca McKinney
A1 Philip B. Mitchell
A1 Marina Mitjans
A1 Francis M. Mondimore
A1 Palmiero Monteleone
A1 Thomas W. Mühleisen
A1 Caroline M. Nievergelt
A1 Markus M. Nöthen
A1 Tomas Novák
A1 John I. Nurnberger, Jr.
A1 Evaristus A. Nwulia
A1 Urban Ösby
A1 Andrea Pfennig
A1 James B. Potash
A1 Peter Propping
A1 Andreas Reif
A1 Eva Reininghaus
A1 John Rice
A1 Marcella Rietschel
A1 Guy A. Rouleau
A1 Janusz K. Rybakowski
A1 Martin Schalling
A1 William A. Scheftner
A1 Peter R. Schofield
A1 Nicholas J. Schork
A1 Thomas G. Schulze
A1 Johannes Schumacher
A1 Barbara W. Schweizer
A1 Giovanni Severino
A1 Tatyana Shekhtman
A1 Paul D. Shilling
A1 Christian Simhandl
A1 Claire M. Slaney
A1 Erin N. Smith
A1 Alessio Squassina
A1 Thomas Stamm
A1 Pavla Stopkova
A1 Fabian Streit
A1 Jana Strohmaier
A1 Szabolcs Szelinger
A1 Sarah K. Tighe
A1 Alfonso Tortorella
A1 Gustavo Turecki
A1 Eduard Vieta
A1 Julia Volkert
A1 Stephanie H. Witt
A1 Adam Wright
A1 Peter P. Zandi
A1 Peng Zhang
A1 Sebastian Zollner
A1 Francis J. McMahon
YR 2016
UL http://biorxiv.org/content/early/2016/03/22/044412.abstract
AB Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ~2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87×10−9; odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53×10−9; odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.BDBipolar DisorderSCZSchizophreniaGWASGenome-wide Association StudySNPSingle Nucleotide PolymorphismMAFMinor Allele FrequencyOROdds RatioSDStandard DeviationCIConfidence IntervaleQTLexpression Quantitative Trait LocusGAIN-NIMHGenetic Association Information Network – National institute of Mental HealthWTCCCWellcome Trust Case Control ConsortiumSTEP-BDSystematic Treatment Enhancement Program for Bipolar DisorderTGENTranslational Genomics Research InstituteConLiGenThe International Consortium on Lithium GeneticsBoMABonn-MannheimdbGaPDatabase of Genotypes and PhenotypesNCPNon-Centrality Parameter