%0 Journal Article %A Liping Hou %A Sarah E. Bergen %A Nirmala Akula %A Jie Song %A Christina M. Hultman %A Mikael Landén %A Mazda Adli %A Martin Alda %A Raffaella Ardau %A Bárbara Arias %A Jean-Michel Aubry %A Lena Backlund %A Judith A. Badner %A Thomas B. Barrett %A Michael Bauer %A Bernhard T. Baune %A Frank Bellivier %A Antonio Benabarre %A Susanne Bengesser %A Wade H. Berrettini %A Abesh Kumar Bhattacharjee %A Joanna M. Biernacka %A Armin Birner %A Cinnamon S. Bloss %A Clara Brichant-Petitjean %A Elise T. Bui %A William Byerley %A Pablo Cervantes %A Caterina Chillotti %A Sven Cichon %A Francesc Colom %A William Coryell %A David W. Craig %A Cristiana Cruceanu %A Piotr M. Czerski %A Tony Davis %A Alexandre Dayer %A Franziska Degenhardt %A Maria Del Zompo %A J. Raymond DePaulo %A Howard J. Edenberg %A Bruno étain %A Peter Falkai %A Tatiana Foroud %A Andreas J. Forstner %A Louise Frisén %A Mark A. Frye %A Janice M. Fullerton %A Sébastien Gard %A Julie S. Garnham %A Elliot S. Gershon %A Fernando S. Goes %A Tiffany A. Greenwood %A Maria Grigoroiu-Serbanescu %A Joanna Hauser %A Urs Heilbronner %A Stefanie Heilmann-Heimbach %A Stefan Herms %A Maria Hipolito %A Shashi Hitturlingappa %A Per Hoffmann %A Andrea Hofmann %A Stephane Jamain %A Esther Jiménez %A Jean-Pierre Kahn %A Layla Kassem %A John R. Kelsoe %A Sarah Kittel-Schneider %A Sebastian Kliwicki %A Daniel L. Koller %A Barbara König %A Nina Lackner %A Gonzalo Laje %A Maren Lang %A Catharina Lavebratt %A William B. Lawson %A Marion Leboyer %A Susan G. Leckband %A Chunyu Liu %A Anna Maaser %A Pamela B. Mahon %A Wolfgang Maier %A Mario Maj %A Mirko Manchia %A Lina Martinsson %A Michael J. McCarthy %A Susan L. McElroy %A Melvin G. McInnis %A Rebecca McKinney %A Philip B. Mitchell %A Marina Mitjans %A Francis M. Mondimore %A Palmiero Monteleone %A Thomas W. Mühleisen %A Caroline M. Nievergelt %A Markus M. Nöthen %A Tomas Novák %A John I. Nurnberger, Jr. %A Evaristus A. Nwulia %A Urban Ösby %A Andrea Pfennig %A James B. Potash %A Peter Propping %A Andreas Reif %A Eva Reininghaus %A John Rice %A Marcella Rietschel %A Guy A. Rouleau %A Janusz K. Rybakowski %A Martin Schalling %A William A. Scheftner %A Peter R. Schofield %A Nicholas J. Schork %A Thomas G. Schulze %A Johannes Schumacher %A Barbara W. Schweizer %A Giovanni Severino %A Tatyana Shekhtman %A Paul D. Shilling %A Christian Simhandl %A Claire M. Slaney %A Erin N. Smith %A Alessio Squassina %A Thomas Stamm %A Pavla Stopkova %A Fabian Streit %A Jana Strohmaier %A Szabolcs Szelinger %A Sarah K. Tighe %A Alfonso Tortorella %A Gustavo Turecki %A Eduard Vieta %A Julia Volkert %A Stephanie H. Witt %A Adam Wright %A Peter P. Zandi %A Peng Zhang %A Sebastian Zollner %A Francis J. McMahon %T Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder %D 2016 %R 10.1101/044412 %J bioRxiv %P 044412 %X Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ~2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87×10−9; odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53×10−9; odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.BDBipolar DisorderSCZSchizophreniaGWASGenome-wide Association StudySNPSingle Nucleotide PolymorphismMAFMinor Allele FrequencyOROdds RatioSDStandard DeviationCIConfidence IntervaleQTLexpression Quantitative Trait LocusGAIN-NIMHGenetic Association Information Network – National institute of Mental HealthWTCCCWellcome Trust Case Control ConsortiumSTEP-BDSystematic Treatment Enhancement Program for Bipolar DisorderTGENTranslational Genomics Research InstituteConLiGenThe International Consortium on Lithium GeneticsBoMABonn-MannheimdbGaPDatabase of Genotypes and PhenotypesNCPNon-Centrality Parameter %U https://www.biorxiv.org/content/biorxiv/early/2016/03/22/044412.full.pdf