TY - JOUR T1 - The Opposing Effects of Hedonic and Eudaimonic Happiness on Gene Expression is Correlated Noise JF - bioRxiv DO - 10.1101/044917 SP - 044917 AU - Jeffrey A. Walker Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/03/20/044917.abstract N2 - Background This paper re-analyzes the gene set data from Fredrickson et al. 2013 [1] and Fredrick-son et al. 2015 [2] which purportedly showed opposing effects of hedonic and eudaimonic happiness on the expression levels of a set of genes that have been correlated with social adversity.Methods Four non-parametric methods were used to test the two null hypotheses addressed in the original studies ( and ) as well as the null hypothesis of no difference in effect between hedonic and eudaimonic happiness ().Results The results unambiguously fail to support opposing effects, or any effect, on the pattern of gene expression.Conclusions The apparently replicated pattern of gene expression is simply “correlated noise” due to the geometry of multiple regression given the strongly correlated measures of hedonic and eudaimonic happiness. ER -