@article {Yang044545, author = {Chen Yang and Justin Chu and Ren{\'e} L Warren and Inan{\c c} Birol}, title = {NanoSim: nanopore sequence read simulator based on statistical characterization}, elocation-id = {044545}, year = {2016}, doi = {10.1101/044545}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Motivation: In 2014, Oxford Nanopore Technologies (ONT) announced a new sequencing platform called MinION. The particular features of MinION reads {\textendash} longer read lengths and single-molecule sequencing in particular {\textendash} show potential for genome characterization. As of yet, the pre-commercial technology is exclusively available through early-access, and only a few datasets are publically available for testing. Further, no software exists that simulates MinION platform reads with genuine ONT characteristics.Results: In this article, we introduce NanoSim, a fast and scalable read simulator that captures the technology-specific features of ONT data, and allows for adjustments upon improvement of nanopore sequencing technology.}, URL = {https://www.biorxiv.org/content/early/2016/03/18/044545.1}, eprint = {https://www.biorxiv.org/content/early/2016/03/18/044545.1.full.pdf}, journal = {bioRxiv} }