RT Journal Article SR Electronic T1 NanoSim: nanopore sequence read simulator based on statistical characterization JF bioRxiv FD Cold Spring Harbor Laboratory SP 044545 DO 10.1101/044545 A1 Chen Yang A1 Justin Chu A1 René L Warren A1 Inanç Birol YR 2016 UL http://biorxiv.org/content/early/2016/03/18/044545.abstract AB Motivation: In 2014, Oxford Nanopore Technologies (ONT) announced a new sequencing platform called MinION. The particular features of MinION reads – longer read lengths and single-molecule sequencing in particular – show potential for genome characterization. As of yet, the pre-commercial technology is exclusively available through early-access, and only a few datasets are publically available for testing. Further, no software exists that simulates MinION platform reads with genuine ONT characteristics.Results: In this article, we introduce NanoSim, a fast and scalable read simulator that captures the technology-specific features of ONT data, and allows for adjustments upon improvement of nanopore sequencing technology.