PT  - JOURNAL ARTICLE
AU  - Chen Yang
AU  - Justin Chu
AU  - René L Warren
AU  - Inanç Birol
TI  - NanoSim: nanopore sequence read simulator based on statistical characterization
AID  - 10.1101/044545
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 044545
4099  - http://biorxiv.org/content/early/2016/03/18/044545.short
4100  - http://biorxiv.org/content/early/2016/03/18/044545.full
AB  - Motivation: In 2014, Oxford Nanopore Technologies (ONT) announced a new sequencing platform called MinION. The particular features of MinION reads – longer read lengths and single-molecule sequencing in particular – show potential for genome characterization. As of yet, the pre-commercial technology is exclusively available through early-access, and only a few datasets are publically available for testing. Further, no software exists that simulates MinION platform reads with genuine ONT characteristics.Results: In this article, we introduce NanoSim, a fast and scalable read simulator that captures the technology-specific features of ONT data, and allows for adjustments upon improvement of nanopore sequencing technology.