RT Journal Article SR Electronic T1 A statistical framework for neuroimaging data analysis based on mutual information estimated via a Gaussian copula JF bioRxiv FD Cold Spring Harbor Laboratory SP 043745 DO 10.1101/043745 A1 Robin A. A. Ince A1 Bruno L. Giordano A1 Christoph Kayser A1 Guillaume A. Rousselet A1 Joachim Gross A1 Philippe G. Schyns YR 2016 UL http://biorxiv.org/content/early/2016/03/16/043745.abstract AB We begin by reviewing the statistical framework of information theory as applicable to neuroimaging data analysis. A major factor hindering wider adoption of this framework in neuroimaging is the difficulty of estimating information theoretic quantities in practice. We present a novel estimation technique that combines the statistical theory of copulas with the closed form solution for the entropy of Gaussian variables. This results in a general, computationally efficient, flexible, and robust multivariate statistical framework that provides effect sizes on a common meaningful scale, allows for unified treatment of discrete, continuous, uni‐ and multi-dimensional variables, and enables direct comparisons of representations from behavioral and brain responses across any recording modality. We validate the use of this estimate as a statistical test within a neuroimaging context, considering both discrete stimulus classes and continuous stimulus features. We also present examples of novel analyses facilitated by these developments, including application of multivariate analyses to MEG planar magnetic field gradients, and pairwise temporal interactions in evoked EEG responses. We show the benefit of considering the instantaneous temporal derivative together with the raw values of M/EEG signals as a multivariate response, how we can separately quantify modulations of amplitude and direction for vector quantities, and how we can measure the emergence of novel information over time in evoked responses. Open-source Matlab and Python code implementing the new methods accompanies this article.HighlightsNovel estimator for mutual information and other information theoretic quantitiesProvides general, efficient, flexible and robust multivariate statistical frameworkValidated statistical performance on EEG and MEG dataApplications to spectral power and phase, 2D magnetic field gradients,temporal derivativesInteraction information relates information content in different responses