%0 Journal Article %A Andika Dwi Mahendra %A M. Kuswandi %A Ika Trisharyanti D. Kusuma %T The Pattern of Bacteria and its Resistance on Adult Sepsis Patient at Dr. Moewardi General Hospital, Indonesia %D 2016 %R 10.1101/044032 %J bioRxiv %P 044032 %X Background Sepsis incidence which related with morbidity and mortality, is globally increasing. Sepsis occurs because of severe infections. Sepsis has life-threatening potential with organ disfungction complication, septic shock, and death. Alteration of resistance pattern always change at certain period. The aim of the study is to investigate the bacteria pattern and its resistance from adult sepsis patient at Dr. Moewardi Regional General Hospital.Methods Isolated bacteria from adult sepsis patient’s blood at Dr. Moewardi Regional General Hospital. 7 bacteria isolates were taken from blood of adult sepsis patient (September - October 2014) and 46 bacteria isolates of secondary data (January - March 2014) at Dr. Moewardi Regional General Hospital. Bacteria isolation was performed based on standard Laboratory of Microbiology of Dr. Moewardi Regional General Hospital. 7 bacteria isolates were tested by using disc diffusion antibiotic on Mueller Hinton and coupled by 46 secondary data.Results The bacteria pattern from adult sepsis patients were Staphylococcus haemolyticus (15,09%), Staphylococcus hominis (15,09%), Escherichia coli (13,21%), and Acinetobacter baumannii (11,32%). Resistance pattern of bacteria on adult sepsis with level of resistant more than 50% as Staphylococcus haemolyticus (ciprofloxacin, erythromycin, levofloxacin, moxifloxacin, and gentamicin), Escherichia coli (gentamicin, ciprofloxacin, and levofloxacin), and Acinetobacter baumannii (gentamicin, ciprofloxacin, levofloxacin, and ceftazidime)Conclutions Based on this research, revealed that the most common bacteria caused sepsis was Gram negative about 64,64% of all bacteria on sepsis patient. The most frequent cause of sepsis was Staphylococcus hominis, Staphylococcus haemolyticus, and Escherichia coli.Abbreviations:IZinhibition zoneSsensitiveRresistantAMPampicillinCNgentamicinLEVlevofloxacineVAvancomycinMTZmetronidazoleMEMmeropenemRDrifampicinCROceftriaxoneCIPciprofloxacineEerythromycinMXFmoxifloxacineTGCtigecyclineLZDlinezolidCEZceftazidimeAKamikacinSulb-cefsulbactam-cefoperazoneNANutrient AgarCLSIclinical and laboratory standards instituteBHIbrain heart infusionCFUcolony-forming unitsTNFtumor necrosis factorIL-6Interleukin 6CRPC-reactive proteinPAMPspathogen-associated molecular patternsDNAdeoxyribonucleic acidCNScentral nervous systemMICminimum inhibitory concentration. %U https://www.biorxiv.org/content/biorxiv/early/2016/03/16/044032.full.pdf