RT Journal Article SR Electronic T1 Synlet: an R package for systemically analyzing synthetic lethal RNA interference screen data JF bioRxiv FD Cold Spring Harbor Laboratory SP 043570 DO 10.1101/043570 A1 Chunxuan Shao A1 Frank Westermann A1 Thomas Höfer YR 2016 UL http://biorxiv.org/content/early/2016/03/15/043570.abstract AB Summary High-throughput synthetic lethal RNA interference (RNAi) screen experiments shed important insights on the filed of cancer researches and drug discovery, but a comprehensive software for analyzing the data was not available yet. We present synlet, an R package provided a complete pipeline to process the synthetic lethal RNAi screens data. Synlet provides several methods to access the screen quality, including Z’ factor and data visualization. B-score and fraction of control or samples normalization methods are implemented in the package. More importantly, synlet facilitates the process of hits selection by implementing several algorithms, providing the possibility to identify high confidence targets.Availability The source code is freely available in Bioconductor (http://bioconductor.org/).Contact c.shao{at}Dkfz-Heidelberg.de