RT Journal Article
SR Electronic
T1 Genome-wide association between transcription factor expression and chromatin accessibility reveals chromatin state regulators
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 043414
DO 10.1101/043414
A1 David Lamparter
A1 Daniel Marbach
A1 Rico Rueedi
A1 Sven Bergmann
A1 Zoltán Kutalik
YR 2016
UL http://biorxiv.org/content/early/2016/03/12/043414.abstract
AB To better understand genome regulation, it is important to uncover the role of transcription factors in the process of chromatin structure establishment and maintenance. Here we present a data-driven approach to systematically characterize transcription factors that are relevant for this process. Our method uses a linear mixed modeling approach to combine data sets of transcription factor binding motif enrichments in open chromatin and gene expression across the same set of cell lines. Applying this approach to the ENCODE data set we confirm already known and imply numerous novel transcription factors in playing a role in the establishment or maintenance of open chromatin.