RT Journal Article
SR Electronic
T1 AnnoLnc: a web server for systematically annotating novel human lncRNAs
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 042655
DO 10.1101/042655
A1 Mei Hou
A1 Xing Tang
A1 Feng Tian
A1 Fangyuan Shi
A1 Fenglin Liu
A1 Ge Gao
YR 2016
UL http://biorxiv.org/content/early/2016/03/07/042655.abstract
AB Although the repertoire of human lncRNAs has rapidly expanded, their biological function and regulation remain largely elusive. Here, we present AnnoLnc (http://annolnc.cbi.pku.edu.cn), an online portal for systematically annotating newly identified human lncRNAs. AnnoLnc offers a full spectrum of annotations covering genomic location, RNA secondary structure, expression, transcriptional regulation, miRNA interaction, protein interaction, genetic association and evolution, as well as an abstraction-based text summary and various intuitive figures to help biologists quickly grasp the essentials. In addition to an intuitive and mobile-friendly Web interactive design, AnnoLnc supports batch analysis and provides JSON-based Web Service APIs for programmatic analysis. To the best of our knowledge, AnnoLnc is the first web server to provide on-the-fly and systematic annotation for newly identified human lncRNAs. Some case studies have shown the power of AnnoLnc to inspire novel hypotheses.