TY - JOUR T1 - AnnoLnc: a web server for systematically annotating novel human lncRNAs JF - bioRxiv DO - 10.1101/042655 SP - 042655 AU - Mei Hou AU - Xing Tang AU - Feng Tian AU - Fangyuan Shi AU - Fenglin Liu AU - Ge Gao Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/03/07/042655.abstract N2 - Although the repertoire of human lncRNAs has rapidly expanded, their biological function and regulation remain largely elusive. Here, we present AnnoLnc (http://annolnc.cbi.pku.edu.cn), an online portal for systematically annotating newly identified human lncRNAs. AnnoLnc offers a full spectrum of annotations covering genomic location, RNA secondary structure, expression, transcriptional regulation, miRNA interaction, protein interaction, genetic association and evolution, as well as an abstraction-based text summary and various intuitive figures to help biologists quickly grasp the essentials. In addition to an intuitive and mobile-friendly Web interactive design, AnnoLnc supports batch analysis and provides JSON-based Web Service APIs for programmatic analysis. To the best of our knowledge, AnnoLnc is the first web server to provide on-the-fly and systematic annotation for newly identified human lncRNAs. Some case studies have shown the power of AnnoLnc to inspire novel hypotheses. ER -