TY - JOUR T1 - <em>In vivo</em> generation of DNA sequence diversity for cellular barcoding JF - bioRxiv DO - 10.1101/004499 SP - 004499 AU - Ian D. Peikon AU - Diana I. Gizatullina AU - Anthony M. Zador Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/04/24/004499.abstract N2 - Heterogeneity is a ubiquitous feature of biological systems. A complete understanding of such systems requires a method for uniquely identifying and tracking individual components and their interactions with each other. We have developed a novel method of uniquely tagging individual cells in vivo with a genetic “barcode” that can be recovered by DNA sequencing. We demonstrate the feasibility of this technique in bacterial cells. This method should prove useful in tracking interactions of cells within a network, and/or heterogeneity within complex biological samples. ER -